99% Purity Pharmaceutical Raw Materials Powder Spironolacton CAS 52-01-7 For

99% Purity Pharmaceutical Raw Material Powder Spironolacton CAS 52-01-7 For Diuretic

 

Quick Detail:

Name: Spironolactone
CAS No.: 52-01-7
Formula: C24H32O4S
Molecular Weight: 416.62
Density: 1.24 g/cm3
Melting Point: 207-208 °C(lit.)
Boiling Point: 597 °C at 760 mmHg
Flash Point: 302.3 °C
Solubility: practically insoluble in water
Appearance: White to Off White Solid

Used as a diuretic, lactone (spironolactone), the active metabolite. Inhibition of aldosterone biosynthesis. Wow effect of blockers for Pakistan It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia.

 

Description:

Spironolactone (INN, BAN, USAN) commonly referred to simply as spiro, and marketed primarily under the brand name Aldactone in most countries, is a synthetic, steroidal antimineralocorticoid and antiandrogen that also has some weak progestogen properties, as well as some indirect estrogen and glucocorticoid effects. It is used primarily as a diuretic and antihypertensive, but may also be employed for the purpose of reducing elevated or unwanted androgen activity in the body. It acts predominantly as an antagonist of the mineralocorticoid (or aldosterone) and androgen receptors, and in relation to its antimineralocorticoid effects, belongs to a class of pharmaceutical drugs known as potassium-sparing diuretics.
Spironolactone is a relatively old drug, having been introduced clinically in 1959. Futterman and Lemberg have predicted that spironolactone will be less commonly used in cardiovascular conditions (e.g., heart failure and hypertension) as the newer agents like the structurally-related compound eplerenone (also an aldosterone antagonist) are more selective and lack many of the side effects and actions of spironolactone that are undesirable in that particular patient population. However, spironolactone remains more widely used as an antiandrogen than eplerenone for patients in whom this effect is a main goal.
It is on the World Health Organizations List of Essential Medicines, a list of the most important medication needed in a basic health system.

 

Application:

Spironolactone is used primarily to treat heart failure, edematous conditions such as nephrotic syndrome or ascites in patients with liver disease, essential hypertension, hypokalemia, secondary hyperaldosteronism (such as occurs with hepatic cirrhosis), and Conns syndrome (primary hyperaldosteronism). On its own.
Because spironolactone reduces the bodys production of testosterone and blocks the androgen receptors, it can cause effects associated with low testosterone levels and hypogonadism in males. For this reason, men are typically not prescribed spironolactone for any longer than a short period of time, e.g. for an acute exacerbation of heart failure. The newer drug, eplerenone has been approved by the U.S. Food and Drug Administration for treatment of heart failure, but lacks the rather potent antiandrogen effects and thus is far more suitable for men for whom long term medication is being chosen. Unlike with some other diuretics, potassium supplementation should not be administered while taking spironolactone as this may cause dangerous elevations in serum potassium levels resulting in hyperkalemia and potentially deadly cardiac arrythmias. Physicians must be careful to monitor potassium levels in both males and females who are taking spironolactone, especially during the first twelve months of use and whenever the dosage is increased.

 

Specification:

Test Items	Specification		Test Results
Description	White or off - white crystalline powder		Off - white crystalline powder
Specific rotation	-56°~-60°		-58.2°
Identification	IR	Matches with working standard	Complies
	HPLC
Solubility	Freely soluble in chloroform and in alcohol; Very slightly soluble in water		Conform
Heavy metals	≤10ppm		＜10ppm
Water	≤0.3%		0.22%
Residue on ignition	≤0.1%		0.05%
Relative material	Maximum impurities ≤0.5%		0.36%
	Total impurities ≤1.0%		0.52%
Assay	98.5~101.0%		99.68%
Conclusion	The specification conform with USP.

 

 

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99% Purity Pharmaceutical Raw Materials Powder Spironolacton CAS 52-01-7 For Images