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Home>Products>Raw Steroid Powders>NSI189 Raw Steroid Powders Nsi-189 Phosphate For Antidepressant CAS 1270138-41-4

NSI189 Raw Steroid Powders Nsi-189 Phosphate For Antidepressant CAS 1270138-41-4
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zhuhai Tianhui Chemical Co.,Ltd.2020-07-10 09:46:19
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Product Details
Name: | NSI-189 | CAS No: | 1270138-41-4 | Assay: | 99% |
Appearance: | White Powder |
Product Description
NSI189 Raw Steroid Powders Nsi-189 Phosphate For Antidepressant CAS -41-4
Quick details :
Product Name: NSI-189
Other Name: [2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]
CAS : -41-4
Purity: 99% min.
Molecular Formula: C22H30N4O
Molecular Weight: 366.50
Min order: 1g
Shipping: By Express DHL with tracking number provided
Describtion:
NSI-189 is a benzylphiperizine-aminiopyridine, nootropic and neurogenic research chemical created by Neuralstem, Inc. that was derived from pyrazine and nicotinamide. Studies have shown that it stimulates neurogenesis of human hippocampus-derived neural stem cells in vivo and vitro . In healthy adult mice, NSI-189 has been shown to increase the hippocampal volume by 20% and reverse behavioral symptoms in mouse depression models, meaning at the source it could address depression . The hippocampus is responsible for spatial navigation, along with the consolidation of information from short-term memory to long-term memory.
The chemical entity stimulates new neuron growth in the hippocampus, which is an area of the brain that is believed to be contributory in conditions such as post-traumatic stress disorder (PTSD), Alzheimers disease, and major depressive disorder (MDD).
COA:
Items of analysis | Specification | Results | |
Appearance | Off-white powder | Confrom | |
Identification | IR and HPLC spectrum shall conform to the standard sample | conform | |
Melting Point | 83ºC~86ºC | 84.3ºC~85.6ºC | |
Loss on Drying | Less than 0.5% | 0.29% | |
Purity(On Dried Base,HPLC) | NLT 99.5 % | 99.62% | |
Total Impurity | Less than 0.5% | 0.33% | |
Residue On Ignition | ≤0.2% | 0.16% | |
Heavy metal | ≤20ppm | conform | |
Conclusion | |
Dosage:
Due to the fact that NSI-189 phosphate is still a trial drug, there has not yet been a fixed dosage. However, during the trials patients were given daily doses of 40mg, 80mg, and 120mg at the highest dose per day over the course of 28 days. During this period, patients did not report any serious events or side effects, and the NSI-189 phosphate was found to be well tolerated. Also, there was a significant reduction in depression and cognitive symptoms for patients taking the lower doses of 40mg and 80mg, but not for those taking 120mg per day. The preliminary findings of the trials are supportive of the idea that NSI-189 phosphate can treat MDD. Nonetheless, further studies on the dosage and the method of action of NSI-189 phosphate are imperative to help confirm preliminary observations and help draw conclusions.
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