White Raw Steroid Powders Abortifacient Mifepristone for Anti - Pregnancy CAS

Raw Steroid Powder Abortifacient Mifepristone for Anti-Pregnancy CAS 84371-65-3

 

Quick Detail:
Product Name: Mifepristone
Synonyms: 11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)-estra-9-dien-3-one;11beta-[4-(n,n-dimethylamino)phenyl]-17alpha-(prop-1-ynyl)-delta4,9-estradiene;17-beta)-(11-bet;17beta)-11-[4-(dimethylamino)-phenyl]-17-hydroxy-17-(1-propynyl)estra-(11bet;17-beta-hydroxy-11-beta-(4-dimethylaminophenyl-1)-17-alpha-(prop-1-ynyl)oest;-17beta-ol-3-one;4,9-dien-3-one;r38486
CAS: 84371-65-3
MF: C29H35NO2
MW: 429.59
Product Categories:Steroids;Hormone;Acetylenes;Biochemistry;
Functionalized Acetylenes;Hydroxyketosteroids;Chiral Reagents;
Intermediates & Fine Chemicals;Pharmaceuticals;Intracellular receptor;Nuclear Receptors;Steroid and Hormone;API;Hormone Drugs
MP 195-198°C
Storage temp. 2-8°C
Chemical Properties : Pale Yellow Solid
Usage : A progesterone receptor antagonist with partial agonist activity. Abortifacient.
Usage : glutamate uptake inhibitor, AMPA blocker

 

Description:
Mifepristone (or RU-486) is a synthetic steroid compound with both antiprogesterone and antiglucocorticoid properties. The compound is a 19-nor steroid with substitutions at positions C11 and C17 (17 beta-hydroxy-11 beta-[4-dimethylamino phenyl] 17 alpha-[1-propynyl]estra-4,9-dien-3-one), which antagonizes cortisol action competitively at the receptor level.

Mifepristone is a progesterone receptor antagonist used as an abortifacient in the first months of pregnancy, and in smaller doses as an emergency contraceptive. It is also a powerful glucocorticoid receptor antagonist, and has occasionally been used in refractory Cushings syndrome (due to ectopic/neoplastic ACTH/cortisol secretion). During early trials, it was known as RU-38486 or simply RU-486, its designation at the Roussel Uclaf company, which designed the drug. The drug was initially made available in France, and other countries then followed-often amid controversy. It is marketed under tradenames Korlym and Mifeprex, according to FDA Orange Book.

 

Applications:

Mifepristone plays a role on the receptor level of new antifertility drugs, no progesterone, androgen, estrogen activity. It has an effect on softening and dilating uterine neck. It is a new anti - progesterone, and anti-glucocorticoid activity, without progesterone, estrogen, androgen and estrogen activity. And progesterone receptor affinity is 5 times stronger than progesterone. For termination of early pregnancy, reinstating menstruation and terminating pregnancy, fetal death, etc. In induction of labor.

 

Specification:

Items of analysis	Specification	Results
Description	Light Yellowish Crystalline Powder	Light Yellowish Crystalline Powder
Identification	he maximum absorption wavelength of 304nm, 260nm, and infrared absorption spectra were consistent with the control product.	Conformity
Melting Point	192ºC~196ºC	192ºC~196ºC
Specific Rotation	+124°~ +129°	+127.3°
Single Impurity	≤0.5%	0.45%
Total Impurity	≤1.0%	0.60%
Loss On Drying	≤0.5%	0.2%
Assay	≥98.5%	99.4%
Sieve analysis	≤30μm	Conformity
Conclusion	Qualified

 

 

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