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Home>Products>Raw Steroid Powders>White Raw Steroid Powders Abortifacient Mifepristone for Anti - Pregnancy CAS

White Raw Steroid Powders Abortifacient Mifepristone for Anti - Pregnancy CAS
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zhuhai Tianhui Chemical Co.,Ltd.2020-07-10 09:46:19
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Product Details
Name: | Mifepristone | CAS: | 84371-65-3 | Assay: | 99% |
Appearance: | White crystalline powder |
Product Description
Raw Steroid Powder Abortifacient Mifepristone for Anti-Pregnancy CAS 84371-65-3
Quick Detail:
Product Name: Mifepristone
Synonyms: 11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)-estra-9-dien-3-one;11beta-[4-(n,n-dimethylamino)phenyl]-17alpha-(prop-1-ynyl)-delta4,9-estradiene;17-beta)-(11-bet;17beta)-11-[4-(dimethylamino)-phenyl]-17-hydroxy-17-(1-propynyl)estra-(11bet;17-beta-hydroxy-11-beta-(4-dimethylaminophenyl-1)-17-alpha-(prop-1-ynyl)oest;-17beta-ol-3-one;4,9-dien-3-one;r38486
CAS: 84371-65-3
MF: C29H35NO2
MW: 429.59
Product Categories:Steroids;Hormone;Acetylenes;Biochemistry;
Functionalized Acetylenes;Hydroxyketosteroids;Chiral Reagents;
Intermediates & Fine Chemicals;Pharmaceuticals;Intracellular receptor;Nuclear Receptors;Steroid and Hormone;API;Hormone Drugs
MP 195-198°C
Storage temp. 2-8°C
Chemical Properties : Pale Yellow Solid
Usage : A progesterone receptor antagonist with partial agonist activity. Abortifacient.
Usage : glutamate uptake inhibitor, AMPA blocker
Description:
Mifepristone (or RU-486) is a synthetic steroid compound with both antiprogesterone and antiglucocorticoid properties. The compound is a 19-nor steroid with substitutions at positions C11 and C17 (17 beta-hydroxy-11 beta-[4-dimethylamino phenyl] 17 alpha-[1-propynyl]estra-4,9-dien-3-one), which antagonizes cortisol action competitively at the receptor level.
Mifepristone is a progesterone receptor antagonist used as an abortifacient in the first months of pregnancy, and in smaller doses as an emergency contraceptive. It is also a powerful glucocorticoid receptor antagonist, and has occasionally been used in refractory Cushings syndrome (due to ectopic/neoplastic ACTH/cortisol secretion). During early trials, it was known as RU-38486 or simply RU-486, its designation at the Roussel Uclaf company, which designed the drug. The drug was initially made available in France, and other countries then followed-often amid controversy. It is marketed under tradenames Korlym and Mifeprex, according to FDA Orange Book.
Applications:
Mifepristone plays a role on the receptor level of new antifertility drugs, no progesterone, androgen, estrogen activity. It has an effect on softening and dilating uterine neck. It is a new anti - progesterone, and anti-glucocorticoid activity, without progesterone, estrogen, androgen and estrogen activity. And progesterone receptor affinity is 5 times stronger than progesterone. For termination of early pregnancy, reinstating menstruation and terminating pregnancy, fetal death, etc. In induction of labor.
Specification:
Items of analysis | Specification | Results | |
Description | Light Yellowish Crystalline Powder | Light Yellowish Crystalline Powder | |
Identification | he maximum absorption wavelength of 304nm, 260nm, and infrared absorption spectra were consistent with the control product. | Conformity | |
Melting Point | 192ºC~196ºC | 192ºC~196ºC | |
Specific Rotation | +124°~ +129° | +127.3° | |
Single Impurity | ≤0.5% | 0.45% | |
Total Impurity | ≤1.0% | 0.60% | |
Loss On Drying | ≤0.5% | 0.2% | |
Assay | ≥98.5% | 99.4% | |
Sieve analysis | ≤30μm | Conformity | |
Conclusion | Qualified |
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