Legal Oral Steroids Toremifene Citrate CAS 89778-27-8 White Powder
Quick Details of Toremifen(e) citrate:
| Product Name |
Toremifen citrate |
| Synonyms |
(z)-4-chloro-1,2-diphenyl-1-(4-(2-(n,n-dimethylamino)ethoxy)phenyl)-1-butene;2-(4-(4-chloro-1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethyl-ethanamin(z)-ethanamin;2-hydroxy-1,2,3-propanetricarboxylate(1:1);fareston;fc1157a;nk622;(z)-2-[4-(4-chloro-1,2-diphenyl-1-butenyl)phenoxy]-n,n-dimethyl-ethanamine 2-hydroxy-1,2,3-propanetricarboxylate |
| CAS No. |
13647-35-3 |
| Molecular Formula |
C32H36ClNO8 |
| Molecular Weight |
598.08 |
| EINECS No. |
-626-2 |
| Melting point |
160-162°C |
| Boiling point |
146-148C |
| Flash point |
277.4ºC |
| Density |
1,045g/cm |
| Solubility |
DMSO: >10mg/mL |
| Refractive index |
1,416-1,418 |
| Appearance |
White Powder |
| Purity |
99% |
| Quality Standard |
Enterprise standard |
| Storage Conditions |
-20°C Freezer |
| Packing |
1kg/foil bag;25kg/drum |
| Shipment |
EMS;DHL;FedEx;TNT;UPS |
| Delivery Time |
4-7 Working Days |
| Payment terms |
T/T;Western Union;Money Gram;Bitcoin |
| Usage |
Treatment of Postmenopausal Women with Estrogen Receptor Positive or Unknown Metastatic Breast Cancer. |
Toremifen(e) citrate Descriptions:
Toremifen(e) citrate, chemical name Z-2-[4-(4-chloro-1, 2-diphenyl)-1-butenyl]phenoxy]-N, N -Dimethyl ethylamine monophthalate, a new generation of anti-estrogen antitumor drug developed by Farmos in Finland in 1979. It is a derivative of non-steroidal tristyryl. It was first developed in Finland in 1988. The listed non-steroidal anti-estrogen antitumor drugs are mainly used for the treatment of breast cancer.
Toremifen(e) citrate Pharmacological effects:
The combination of toremifen(e) citrate with estrogen receptors can produce estrogen-like or anti-estrogen effects, or both, depending on the length of treatment, animal species, sex, and target organ. In general, non-steroidal tristyryl derivatives act primarily as anti-estrogen in humans and rats and as estrogen-like effects in mice. The use of toremifen(e) in postmenopausal breast cancer patients induced a moderate decrease in serum total cholesterol and low density lipoprotein (LDL). Toremifen(e) citrate and estrogen competitively bind to estrogen receptors in cytoplasm of breast cancer cells, preventing estrogen-induced DNA synthesis and proliferation in cancer cells. A large dose of toremifen(e) citrate was used in some experimental tumors, demonstrating the non-estrogen-dependent antitumor effects of toremifen(e) citrate. The anti-breast cancer effect of toremifen(e) citrate is mainly an anti-estrogen effect, and may also have other anti-cancer mechanisms (change in tumor gene expression, secrete growth factors, induce apoptosis, and affect cell cycle dynamics).
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Our company is a professional raw powder factory in China for over 10 years, all powders are factory directly supplying. |
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Our products have exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month. |
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Legal Oral Steroids Toremifene Citrate CAS 89778-27-8 White Powder Images
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zhuhai Tianhui Chemical Co.,Ltd.2020-07-10 09:46:19
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